Changzhou Smart-Lifesciences Biotechnology Co.,Ltd.

Protein L is a protein isolated from Peptostreptococcus magnus and can bind to immunoglobulins. Recombinant Protein L is expressed by Escherichia coli and has a molecular weight of about 18 kDa (SDS-PAGE). It retains the property of binding to the antibodies kappa light chain without affecting the antigen binding site of antibodies. Therefore, compared with Protein A and Protein G, Protein L can bind all types of immunoglobulins (IgA, IgD, IgE, IgG, and IgM), and can bind a wide range of antibodies. Protein L binds weakly to rabbit immunoglobulins and does not bind to immunoglobulins of bovine, goat, or sheep origin. Protein L can also bind single chain antibodies (scFv) and Fab fragments, which has a wide range of applications.